Galiana's New Nanotechnology - A Brain Computer Interface for Humankind

Galiana's New Nanotechnology - A Brain Computer Interface for Humankind Galiana's New Nanotechnology - A Brain Computer Interface for Humankind Galiana's New Nanotechnology - A Brain Computer Interface for Humankind

Pioneering high-resolution brain computer interfaces to revolutionize mobility for individuals affected by neuromuscular disorders. We are empowering lives through advancements in nanotechnology and intracellular techniques, all achieved without the necessity for permanent invasive brain surgery.

our mission

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A New Horizon in Neurological Restoration

  

  Galiana Technology Inc. is dedicated to transforming the lives of individuals with neuromuscular injuries and disorders due to spinal cord damage, ALS, limb loss, diabetes, and more. We envision a future where groundbreaking neurological solutions are accessible, safe, and profoundly life-changing.

  Millions face these debilitating challenges, with current brain-computer interface (BCI) solutions often requiring invasive brain surgery to implant electrodes that reliably record only a few dozen neurons, and then gradually lose function when the brain recognizes it as a foreign object. Galiana is poised to change this paradigm. 

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How are We Doing This?

  The human brain encodes specific movements by activating fleeting 'patterns' of sparsely distributed neurons, called ensembles, similar to how information is encoded by pixel patterns in QR codes. Recording millions of neurons in these ensembles would allow disabled individuals to control limbs or prosthetics with near-normal precision. To achieve this, we are developing a completely new type of BCI technology using nanofids—micron-sized electronic devices inside neurons where they can provide single-neuron resolution recordings of all neurons across the cortex.  When neurons are activated, nanofids emit unique near-infrared codes that are captured by a non-invasive optical fiber array and decoded via solid-state systems, converting neural activity into high-speed digital signals for real-time AI-driven analysis and motor control.

Close-up of a neuron with glowing dendrites against a dark background.

The Non-Invasive Revolution: Intracellular Devices for Single Neuron Precision

  Unlike conventional approaches, our innovative solution achieves direct communication from microscopic devices inside the neuron, without the need for chronic, permanently implanted electrodes in the brain. 

  Our patented Intracellular Monitoring Devices (IMDs) (U.S. Patent #12268512-B2) called nanofids are introduced using temporary micro-needling technology. Once inserted into the brain, nanofids are absorbed into neurons and the device becomes a silent observer—ultralight, motion-tolerant, requiring no genetic manipulation and minimal signal processing. And unlike the probes of today that struggle to interface with the living brain, nanofids whisper their messages from inside the cell without being exposed to and rejected by the brain's immune system, and without continuing mechanical tissue damage, meaning: 


  • Significantly reduced surgical risk & recovery, 
  • Enhanced patient safety & acceptance, 
  • True single neuron precision for high-resolution data, and 
  • The potential for broader application in addressing neuromuscular disorders through advanced nanotechnology.

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Validated Science, Trusted Partnerships

Our foundational technology is rigorously validated through:  


  • Successful In-Vivo Testing: Pioneering in-vivo studies have confirmed the absorption of silica nanofid proxies into neurons, where our nanofids will detect neural activity, enhancing the capabilities of brain computer interfaces  
  • Wallace et al (2017) Cellular and Molecular Neurobiology: DOI 10.1007/s10571-017-0479-z
  • UCSD's Jacobs School of Engineering (Prof. Oscar Vasquez-Mena): Collaborating with a leader in nano-bio integration and biomedical microdevices fortifies our engineering and material science capabilities, particularly in the field of nanotechnology  
  • Hope Labs at NIH - NIDA: Our partnership with the Hope lab at National Institute on Drug Abuse (NIDA) provides invaluable guidance about the neuroscience of encoding information in the brain, the biology for optimal interface design and testing, and stringent ethical, societal, and regulatory standards for brain interfaces. This collaboration also validates the broader potential of our technology beyond quadriplegia, extending to various neuromuscular disorders and neurological ailments, including addictive behavior treatment, leveraging NIDA's extensive research into neural systems

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Pioneering Progress: Meet Our Leadership Team

Galiana Technology Inc. is driven by a powerful synergy of seasoned leadership and cutting-edge engineering expertise in brain-computer interface (BCI) technologies:


Mark A. Wells, President: A veteran in scaling disruptive technologies, Mark is the co-inventor of our core patent and brings over two decades of experience in the wireless, IoT, and tech startup sectors. With a history of founding, growing, and successfully exiting companies (including Zucotto Wireless and DSP Communications, acquired by Intel), Mark's business acumen, product strategy, and materials science background are invaluable to Galiana's trajectory in developing high-resolution solutions for neuromuscular disorders.


Gregory Sutton, Engineer: A key engineer and co-inventor of our core patent, Gregory provides profound scientific and engineering expertise in bio-inspired robotics, neuro-mechanics, and neural control. His deep understanding of neural circuits and biomechanics is critical to developing our advanced BMI solutions that utilize nanotechnology for precise limb control, addressing intracellular challenges in the treatment of neuromuscular disorders.

A human figure with imagery of brain computer interface.

Transforming Lives, Expanding Horizons

  The global market for neurological solutions and assistive technologies represents a significant and growing opportunity. By offering a dramatically less invasive and highly precise BCI, Galiana aims to unlock new possibilities for patient populations previously unreachable or hesitant due to long-term surgical implants. 

  Our technology's versatility, supported by collaborations like NIH-NIDA, also positions Galiana to address a wider spectrum of neurological challenges, from motor control to potential interventions for complex neural disorders. We are not just building a product; we are laying the foundation for a future where advanced brain interfaces empower greater independence and enhance human well-being on an unprecedented scale.

Close-up of a woman with digital data and images overlay.

Unlocking the Human Mind: A New Frontier in Brain-AI Integration

  What if we could read the full language of thought—not just fragments, but the complex symphony of abstract ideas, memories, emotions, and intentions that define what it means to be human? 

  To achieve this, we must move beyond today’s limits and imagine a system capable of recording binarized neural activity from all 30 billion neurons in the human cortex. The human brain encodes meaning not through bulk changes in neural activity, but via activating intricate, fleeting ‘patterns’ of sparsely distributed neurons, called neuronal ensembles, analogous to how information is encoded by pixel ‘patterns’ in a QR code. Each ensemble is a unit of thought, and with enough of them, AI can begin to map the living architecture of cognition. 

  But there is a problem. Today's technologies—electrode arrays and calcium imaging—capture mere thousands of neurons at best in freely moving animals, and even fewer in humans. And biological and physical constraints make it virtually impossible for them to ever reach beyond 0.1% of neurons in the cortex. Thus, the resolution needed to decode full cognition has been out of reach... until now. 

  We are pioneering a breakthrough system based on one-micron-sized intracellular sensors called nanofids—a radically new interface technology that aims to reach every neuron in the human cortex with single-neuron resolution. Each nanofid responds to neural activity by emitting a unique near-infrared (NIR) optical code, serving as a digital beacon of that neuron’s activation. This NIR signal is then captured by a non-invasive optical fiber array and rapidly decoded using a solid-state optical sorting system, converting biological activity into high-speed digital signals ready for real-time AI analysis. 

  Once inserted, a nanofid becomes a silent observer inside the neuron—ultralight, motion-tolerant, requiring no genetic manipulation and minimal signal processing. Unlike the probes of today that struggle to interface with the living brain, nanofids whisper their messages without damaging tissue or being rejected by the brain's immune system. 

  This is not just a brain-computer interface. It is a neural mirror—one that reflects the true complexity and resolution of the human mind in real time and unlocks a new era of cognitive symbiosis between humans and AI. 

  We’re not just reading signals. We’re decoding consciousness.

Close-up of a molecular structure with transparent blue spheres connected by rods.

Ready to Partner with Innovation?

Galiana Technology Inc. is actively seeking strategic investment to accelerate our pre-clinical development of advanced brain computer interface technologies using high resolution and intracellular methods. This funding will help us expand our research capabilities and advance towards human clinical trials aimed at treating neuromuscular disorders through innovative nanotechnology solutions. Join us in shaping the future of neuro-rehabilitation and beyond.

Learn More

News

Patent Information

US Patent 11,627,907: Method and System for the Capture of Intracellular Activity Utilizing Nanotechnology. This innovative approach leverages nanotechnology to enhance the monitoring of intracellular processes. US Patent 12,268,512: Method and System for the Capture of Intracellular Activity with Applications in Brain Computer Interfaces for High Resolution data. This patent focuses on utilizing high-resolution data from intracellular activity to improve brain computer interfaces. US Patent Application 9/799,904: Method and System for the Capture of Intracellular Activity with Nanofids, addressing neuromuscular disorders. This application aims to provide solutions for neuromuscular disorders by effectively capturing intracellular activity.

Galiana Technology and UCSD's Jacobs School of Engineering Collaboration

DARPA DSO Grant # D18AP0062


Galiana Technology, in collaboration with UCSD researcher Dr. Oscar Vazquez Mena, has secured funding from July 2021 to June 2023 for the development of nanotechnology aimed at enhancing brain-computer interfaces. This project focuses on reducing all component sizes to 10-100 microns, manufacturing and testing a high-resolution calcium sensor, and conducting end-to-end simulations. These simulations will demonstrate the feasibility of design, power, and signal processing, particularly in applications related to intracellular signals and neuromuscular disorders.


See UCSD News Release for more info - https://jacobsschool.ucsd.edu/news/release/3258?id=3258#https://jacobsschool.ucsd.edu/news/release/3258%20

Galiana Technology Receives Grant for Neural Nanoscale Circuit Development

Friday, April 10th, 2015


San Diego, CA – Galiana Technology, an emerging growth company specializing in brain computer interface technology, received a grant on September 10, 2014. This grant, endowed by the National Institutes of Health (NIH), aims to develop a high resolution electrical circuit prototype for intracellular neural recording at the nanoscale, which is crucial for advancing treatments for neuromuscular disorders through innovative nanotechnology.

Contact Us

We are actively seeking investments. Interested?

Contact us for more information about brain computer interfaces and their role in high resolution applications, along with advancements in intracellular research and nanotechnology aimed at treating neuromuscular disorders.

Galiana Technology

7071 Convoy Court, #300 San Diego CA 92111

(858) 205-4126

Mark A. Wells

President

mark@galianatechnology.com

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